Biological evaluation of octahydropyrazin [2, 1-a: 5, 4-a′] diisoquinoline derivatives as potent anticancer agents
A Gornowicz, N Pawłowska, A Czajkowska… - … Biology, 2017 - journals.sagepub.com
… In this study, we examined the cytotoxicity and antiproliferative potential of seven novel
octahydropyrazin[2,1-a:5,4-a′]diisoquinoline derivatives (1–7) (Figure 1) in estrogen receptor–…
octahydropyrazin[2,1-a:5,4-a′]diisoquinoline derivatives (1–7) (Figure 1) in estrogen receptor–…
Cytotoxic activity of octahydropyrazin [2, 1-a: 5, 4-a′] diisoquinoline derivatives in human breast cancer cells
M Lepiarczyk, Z Kałuża, A Bielawska… - Archives of Pharmacal …, 2015 - Springer
… The mitochondrial pathway can be activated by a diverse range of stimuli, including reactive
oxygen species, radiation and chemotherapeutic agents. Either caspase 8 or caspase 9 can …
oxygen species, radiation and chemotherapeutic agents. Either caspase 8 or caspase 9 can …
[HTML][HTML] The molecular mechanism of anticancer action of novel octahydropyrazino [2, 1-a: 5, 4-a′] diisoquinoline derivatives in human gastric cancer cells
N Pawłowska, A Gornowicz, A Bielawska… - … New Drugs, 2018 - Springer
… chemotherapeutic agent in gastric cancer treatment. The effect of the tested compounds (1, …
Our results suggest that novel diisoquinoline derivatives might be promising agents in gastric …
Our results suggest that novel diisoquinoline derivatives might be promising agents in gastric …
[HTML][HTML] Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer …
A Czajkowska, A Gornowicz, N Pawłowska… - BioMed research …, 2017 - hindawi.com
… Our studies suggest that cytotoxic activity of chemotherapeutic agents (OM-90, etoposide)
is enhanced by Nigella sativa oil or extract. Our results contradict with the study performed by …
is enhanced by Nigella sativa oil or extract. Our results contradict with the study performed by …
[HTML][HTML] Monoclonal anti‑MUC1 antibody with novel octahydropyrazino [2, 1‑a: 5, 4‑a'] diisoquinoline derivative as a potential multi‑targeted strategy in MCF‑7 breast …
A Gornowicz, W Szymanowski… - Oncology …, 2019 - spandidos-publications.com
… that the new diisoquinoline derivatives could modulate both … novel octahydropyrazin[2,1-a:5,4-a′]diisoquinoline
derivative (OM… Anticancer agents can be designed to target specific cell …
derivative (OM… Anticancer agents can be designed to target specific cell …
The anticancer action of a novel 1, 2, 4-triazine sulfonamide derivative in colon cancer cells
A Gornowicz, A Szymanowska, M Mojzych… - Molecules, 2021 - mdpi.com
… two or three chemotherapeutic agents paired with biologics such as anti-VEGF agents or
anti-EGFR drugs… and a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative (OM-86II…
anti-EGFR drugs… and a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative (OM-86II…
Lasiokaurin derivatives: synthesis, antimicrobial and antitumor biological evaluation, and apoptosis-inducing effects
D Li, P Hu, S Xu, C Fang, S Tang, X Wang… - Archives of Pharmacal …, 2017 - Springer
… Rabdosia rubescens and the whole plant was used as antibacterial and antitumor agents.
At this point, the biological properties of lasiokaurin and its derivatives needed to be revealed. …
At this point, the biological properties of lasiokaurin and its derivatives needed to be revealed. …
[HTML][HTML] Mucin 1 as a molecular target of a novel diisoquinoline derivative combined with anti-MUC1 antibody in AGS gastric cancer cells
A Gornowicz, W Szymanowski, K Bielawski, Z Kałuża… - Molecules, 2021 - mdpi.com
… with the novel diisoquinoline derivative caused a decrease in … and 48 h of incubation,
respectively (Figure 4A,B). Taking into … that the combination of the chemotherapeutic agent with …
respectively (Figure 4A,B). Taking into … that the combination of the chemotherapeutic agent with …
The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon …
A Gornowicz, A Szymanowska, M Mojzych… - International Journal of …, 2020 - mdpi.com
… novel approaches and new chemotherapeutic agents. Other … new biologically active molecules,
including anticancer activity… range of biological activities. Many mono and condensed 1,…
including anticancer activity… range of biological activities. Many mono and condensed 1,…
Antitumor and antibacterial derivatives of oridonin: A main composition of Dong-Ling-Cao
D Li, T Han, S Xu, T Zhou, K Tian, X Hu, K Cheng, Z Li… - Molecules, 2016 - mdpi.com
… Among the derivatives 2–12, 2 and 10 were weaker than parent compound 1, and the
others showed similar or better activity. As for 2–5 with R of aliphatic substituents, 4 was the …
others showed similar or better activity. As for 2–5 with R of aliphatic substituents, 4 was the …